1-Acetyl-4-(4-Hydroxyphenyl)piperazine (AHPP)
A key pharmaceutical intermediate used in the manufacture of ketoconazole and related azole antifungal APIs.
Key intermediate for ketoconazole synthesis
1-Acetyl-4-(4-Hydroxyphenyl)piperazine (AHPP) is a key pharmaceutical intermediate used primarily in the synthesis of ketoconazole, a broad-spectrum azole antifungal API. Its reliable supply and consistent purity directly affect the quality of the downstream product.
Also known as 4-(1-acetylpiperazin-4-yl)phenol, AHPP contributes the acetyl-piperazine / phenol fragment that forms part of the azole antifungal scaffold. Consistent quality at this stage is critical to efficient, high-yield downstream manufacturing.
Its role
Core building block
Provides the acetyl-piperazine / phenol fragment used to build the azole antifungal scaffold.
Ketoconazole route
A key intermediate step in the manufacture of ketoconazole APIs.
Upstream quality
Consistent quality upstream ensures consistent downstream API.
Key applications
API intermediate
Intermediate for ketoconazole and related azole antifungal APIs.
Reference standard
Used as an impurity / reference standard in analytical work.
Specialty chemicals
Specialty pharmaceutical and fine-chemical formulations.
Product specifications (typical)
| CAS No. | 67914-60-7 |
|---|---|
| Molecular Formula | C12H16N2O2 |
| Molecular Weight | ≈ 220.27 g/mol |
| Appearance | White to off-white crystalline powder / solid |
| Assay / Purity | As per agreed specification (high-purity grades available) |
| Category | API intermediate |
High-purity grades supplied to your agreed specification, with COA and SDS on every shipment.
Quality & compliance
- Reliable intermediate supply for downstream API manufacturing
- Consistent purity with documented specifications (COA, SDS)
Packaging & storage
Supplied in HDPE / fibre drums or as required. Store in a cool, dry, ventilated area away from incompatible materials.
Why choose Narmada Organics
Dependable, high-purity intermediate supply for synthesis programmes.
Flexible batch sizes to support scale-up manufacturing.
COA and SDS on every shipment, with global export.
Frequently asked questions
Is AHPP an intermediate or a finished API?
It is a key pharmaceutical intermediate, used primarily in the synthesis of ketoconazole and related azole antifungal APIs.
What purity grades are available?
High-purity grades supplied to your agreed specification, with COA.
Can you supply consistent quality for scale-up manufacturing?
Yes — consistent, documented purity with flexible batch sizes for reliable downstream production.
Do you export and provide documentation?
Yes — global export with COA and SDS on every shipment.
Need high-purity AHPP for synthesis?
Get specifications, COA and pricing with flexible batch sizes. Our team responds within one business day.